The major objective of this study was to evaluate gastro protective effect of hexane extract, ethyl acetate extract, ethanolic extract of annona muricata Linn at dose of 200mg,100mg per kg b.w, was administered orally twice daily for 5 days using pylorus - ligation ulcer model in wistar albino rats. Estimation of various gastric fluids such as volume of gastric juice, total acidity, Free acidity, pH values were done. ulcer index and percentage protection were determined, all the results obtained were compared with the control group and from the results it was found that chloroform extract treated group has shown dose dependent highly significant gastoprotective action. Thus validating the folklore usage of annona muricata as an antiulcer drug.
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